Jurnal

PERAN VITAMIN D DALAM REGULASI SISTEM IMUNITAS MELALUI SEL DENDRITIK

Wira Daramatasia
Program Studi Ilmu Keperawatan
STIKES Widyagama Husada

 

ABSTRACT
Dendritic cells are antigen presenting cells (APC) that initiate professional cellular
immune response and humoral immunity. Differentiation and maturation of dendritic
cells affects their capacity. Known differentiation and maturation of dendritic cells is
affected vitamin D. The purpose of this paper was to determine the mechanism of
vitamin D in regulating the immune response by dendritic cells. Vitamin D has the
effect of inhibiting monocyte differentiation into dendritic cells and inhibits dendritic cell
maturation process, and maintain in a state of immature dendritic cells. Vitamin D
inhibits T cell-dependent activation of dendritic cells, reduce the secretion of Th1 and
Th2 cytokines and induce regulatory T cell development.

Key words: Vitamin D, Dendritic Cells


ABSTRAK
Sel dendritik merupakan antigen presenting cells (APC) profesional yang mengawali respon imunitas
seluler dan imunitas humoral. Differensiasi dan maturasi sel dendritik mempengaruhi kapasitasnya.
Diketahui differensiasi dan maturasi sel dendritik dipengaruhi vitamin D. Tujuan dari makalah ini
adalah mengetahui mekanisme vitamin D dalam regulasi sistem imun melalui sel dendritik. Vitamin D
memiliki efek menghambat differensiasi sel monosit menjadi sel dendritik dan menghambat proses maturasi
sel dendritik, kemudian mempertahankan sel dendritik dalam kondisi imatur. Vitamin D menghambat
aktivasi sel T yang tergantung sel dendritik, menurunkan sekresi sitokin Th1 dan Th2 serta menginduksi
perkembangan sel T regulator.

Kata Kunci : Vitamin D, Sel Dendritik



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