Zainabur Rahmah
Program Studi Kesehatan Lingkungan


Apoptosis occurs during normal and abnormal pregnancy. Apoptosis has been demonstrated occurs in
smooth muscle cell (VSMC) desidual and amniotic membrane. The purpose of this paper is to determine
the mechanism of apoptosis of smooth muscle cell (VSMC), decidual and amniotic membrane in normal
and abnormal pregnancies. Apoptosis in normal pregnancy VSMC express TRAIL (DR4 and DR5)
that cause apoptosis in VSMC associated with remodeling uterine spiral arteries in the first trimester of
pregnancy. In the induction of apoptosis in the desidua by steroid hormones such as estrogen, progesterone
and hCG improved so that the regulation of FasL in the desidua basalis that play a role in the process
of implantation. Apoptosis in the amniotic membrane, there are two paths namely death receptor pathway
and mitochondrial pathway.

Keywords: Apoptosis, Pregnancy Normal, Abnormal Pregnancy

Apoptosis terjadi selama kehamilan normal dan abnormal. Apoptosis telah ditunjukkan terjadi di dalam
smooth muscle cell (VSMC) membran desidua dan membran amnion. Tujuan dari makalah ini adalah
untuk menentukan mekanisme apoptosis smooth muscle cell (VSMC), desidua dan membran ketuban
pada kehamilan yang normal dan abnormal. Apoptosis pada kehamilan normal VSMC mensekpresikan
TRAIL (DR4 dan DR5) yang menyebabkan apoptosis pada VSMC terkait dengan renovasi arteri
spiralis uterus pada trimester pertama kehamilan. Apoptosis pada desidua diinduksi oleh hormon steroid
seperti estrogen, progesteron dan hCG sehingga meningkatkan regulasi FasL dalam desidua basalis
yang memainkan peran dalam proses implantasi. Apoptosis pada membran ketuban ada dua jalur
yaitu jalur kematian reseptor dan jalur mitokondria.

Kata kunci: Apoptosis, Kehamilan Normal, Kehamilan Abnormal

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